|Test List||A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #|
HE4, Ovarian Cancer MonitoringTest Code
0.5 mL serum
Other Acceptable Specimens
Red top tube
SST (speckled top) tube
Sample collected in a red-top tube must be allowed to clot for at least 30 minutes but no longer than 1 hour.
Red-top tube (no gel)
Room Temperature = 48 hours
Refrigerated = 72 hours
Frozen = 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Lipemia • Icteric specimens • Presence of fibrin, RBCs or other particulate matter • Obvious microbial contamination
Chemiluminescent Microparticle Immunoassay (CMIA)
A clinical study indicated that serial HE4 levels correlated with clinical status (progression vs. no progression) in 70% (247/354) of the study participants.
|Female Premenopausal||≤70 pmol/L|
|Female Postmenopausal||≤140 pmol/L|
The percentage increase in HE4 values has been used as an aid in monitoring recurrence or progressive disease in patients with invasive epithelial ovarian cancer. Currently there is no clinically accepted cut-off for use in monitoring cancer progression in epithelial ovarian cancer subjects with this assay. Serial testing for patient HE4 assay values should be used in conjunction with methods used for monitoring ovarian cancer.